COMPARATIVE PHARMACOKINETICS OF FENTANYL AND ALFENTANIL

The pharmacokinetics of fentanyl, sufentanil and alfentanil: a comparative review.

Fentanyl/alfentanil for pelvic laparoscopy.

Alfentanil, a new narcotic analgesic, was compared to fentanyl in a technique of balanced anaesthesia using thiopentone 5 mg X kg-1 for induction of anaesthesia, and pancuronium 60 micrograms X kg-1 to facilitate intubation. The study group consisted of 80 female patients scheduled for pelvic laparoscopy. The total dose of alfentanil averaged 2.06 mg (range 1.5-2.5 mg) whereas the dose of fenta...

Fentanyl, sufentanil, alfentanil and myocardial function.

REFERENCE 1 Miller DR, WellwoodM, Teasdale SJ et al. Effects of anaesthetic induction on myocardial function and metabolism: a comparison of fentanyl, sufentanil and alfentanil. Can J Anaes 1988; 35: 219-33. on-line pressure-volume loop eapability to pin-point more precisely ventricular cad systole for future studies. Finally, although the negative effects on cardiac function were observed, to ...

Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil.

BACKGROUND Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to characterize the rate and extent of opioid distribution within cerebrospinal fluid, spinal cord, epidural space, and systemic circulation after intrathecal injection. METHODS Equal doses of morphine and alfentanil, fentanyl, or sufe...

Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs.

Remifentanil is an esterase-metabolized opioid developed for use in anesthesia. The principal metabolite of remifentanil, GR90291, is considered to be less potent. This study determined the relative potency of GR90291 and alfentanil, compared with remifentanil, in anesthetized dogs. Male dogs received thiamylal sodium, and anesthesia was maintained using isoflurane and N2O in oxygen. Each dog r...